Characterizing isomiR variants within the micro RNA ‐34/449 family

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Characterizing isomiR variants within the microRNA‐34/449 family

miR-34/449 microRNAs are conserved regulators of multiciliated cell differentiation. Here, we evidence and characterize expression of two isomiR variant sequences from the miR-34/449 family in human airway epithelial cells. These isomiRs differ from their canonical counterparts miR-34b and miR-449c by one supplemental uridine at their 5'-end, leading to a one-base shift in their seed region. Ov...

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ژورنال

عنوان ژورنال: FEBS Letters

سال: 2017

ISSN: 0014-5793,1873-3468

DOI: 10.1002/1873-3468.12595